A IASP (Associação Internacional de Estudo da Dor ) promove em 2016 o ano de combate a Dor Articular.
Pois bem, hoje recebi via email um convite para webinário que achei interessante e dentro desta temática: o papel dos anticorpos na dor articular por artrite reumatóide. O foco será a dor persistente.
Como sabemos a artrite reumatóide pode atingir as articulações temporomandibulares (ATM) e devemos conhecer o tratamento médico realizado pata esta condição para entender os casos que recebemos, sobretudo os crônicos.
Esta é uma ótima oportunidade!
A aula será pela internet e em seguida acontecerá um debate.
Acontecerá na terça-feira, dia 19/04.
Seguem detalhes do evento:
Here is an abstract of Svensson’s talk:
Joint pain in rheumatoid arthritis (RA) often precedes joint inflammation and may persist even after successful anti-inflammatory treatment. RA is a chronic autoimmune disease, and one type of neuroimmune interaction that has recently received some attention is the potential pathogenic role of autoantibodies in maladaptive pain states. We have addressed the possibility that anti-collagen type II (CII) antibodies and anti-citrullinated protein antibodies (ACPAs), present in patients with RA, may be directly responsible for the induction of pain, independent of inflammation. For example, we found that mice injected with either human ACPA IgG purified from RA patients, or murinized monoclonal ACPAs generated from synovial B cells from RA patients, developed long-lasting, pronounced evoked and spontaneous pain-like behavior in the absence of visible and histological signs of inflammation. Non-ACPA IgG from RA patients or control monoclonal IgG were without pro-nociceptive effects. We coupled this to an ACPA-mediated increase in osteoclast activity and subsequent release of pro-nociceptive CXCL1 (IL-8) release. This presentation will highlight roles of autoantibodies in the pathogenesis of persistent pain states and focus on mechanisms by which CII antibodies and ACPAs activate sensory neurons in particular. The identification of novel contributions of autoantibodies to persistent pain may aid in the development of new treatment strategies, not only for pain in RA, but also for pain in other conditions associated with autoantibody production.
Audience participation is encouraged—get ready to submit your questions live to our panel of experts!
During the live discussion, participants will be able to submit questions to the panel. You can also submit questions now, by emailing them to firstname.lastname@example.org.
The webinar is free but registration is required.
Veja a página com mais explicações: http://www.painresearchforum.org/forums/webinar/65510-webinar-role-autoantibodies-rheumatoid-arthritis-joint-pain
A professora e pesquisadora Liete Zwir estará também no II Encontro Paranaense da SBDOF falando sobre degeneração em ATM.
Vale a pena assistir a aula da Liete! Eu garanto! 🙂
Inscrições em www.gapedor.com.br